Atovaquone-Proguanil 250mg-100mg Tablet UK

Atovaquone-Proguanil 250mg-100mg Tablet UK
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Product Details

Atovaquone-Proguanil 250-100mg Tablet UK is available online here. If you don't have a prescription for Atovaquone 250mg Proguanil 100mg Tablets UK, click the green banner above 'Buy now' to access our UK online doctor service. The Atovaquone 250mg Proguanil 100mg Tablets could be with you as soon as tomorrow from our UK registered online pharmacy.

Ingredients

Atovaquone 250mg plus Proguanil 100mg

Warnings

UK Package leaflet: Information for the user:
Atovaquone/Proguanil hydrochloride 250 mg/100 mg film-coated tablets

Read right through this leaflet carefully before you start taking this medicine.
This medicine has been prescribed for you personally. Don't pass it on to other people - it may harm
them even if their symptoms seem to be the same as yours.
Keep this leaflet. You may need to read it again.
If you have any questions, ask your doctor or pharmacist (chemist).
If you have serious side effects, or if you notice any side effects not listed in this leaflet, tell your
doctor or pharmacist.
__________________________________________________________________________________
In this leaflet:
1. What Atovaquone/Proguanil is and what it's for
2. Before you take Atovaquone/Proguanil
3. While you're taking Atovaquone/Proguanil
4. How to take Atovaquone/Proguanil
5. Possible side effects
6. How to store Atovaquone/Proguanil
7. Further information
1. What Atovaquone/Proguanil is and what it's for
Atovaquone/Proguanil belongs to a group of medicines called antimalarials. It contains two active ingredients, atovaquone and proguanil hydrochloride.
What Atovaquone/Proguanil is for
Atovaquone/Proguanil has two uses:
 to prevent malaria
 to treat malaria
Dosage instructions for each use are in Section 4, How to take Atovaquone/Proguanil.
Malaria is spread by the bite of an infected mosquito, which passes the malaria parasite (Plasmodium
falciparum) into the bloodstream. Atovaquone/Proguanil prevents malaria by killing this parasite. For people who
are already infected with malaria, Atovaquone/Proguanil also kills these parasites.
Protect yourself from catching malaria.
People of any age can get malaria. It is a serious disease, but is preventable.
As well as taking Atovaquone/Proguanil, it is very important that you also take steps to avoid being bitten by mosquitoes.
 Use insect repellent on exposed areas of the skin
 Wear light coloured clothing that covers most of the body, especially after sunset as this is the time when mosquitoes are most active

 Sleep in a screened room or under a mosquito net impregnated with insecticide
 Close windows and doors at sunset, if they are not screened
 Consider using an insecticide (mats, spray, plug-ins) to clear a room of insects or to deter mosquitoes from entering the room.
→ If you need further advice, talk to your doctor or pharmacist.
It is still possible to get malaria after taking the necessary precautions. Some types of malaria infection take a long time to cause symptoms, so the illness may not start until several days, weeks or even months after returning from abroad.
→ See a doctor immediately if you get symptoms such as high temperature, headache, shivering and tiredness after returning home.
2. Before you take Atovaquone/Proguanil
Do not take Atovaquone/Proguanil:
 if you are allergic (hypersensitive) to atovaquone, proguanil hydrochloride or any ingredient
 for preventing malaria, if you have severe kidney disease.
→ Tell your doctor if either of these apply to you.
Pregnancy and breast feeding
If you are pregnant, do not take Atovaquone/Proguanil unless your doctor recommends it.
→ Ask your doctor or pharmacist for advice before taking Atovaquone/Proguanil
Do not breast feed while taking Atovaquone/Proguanil, as the ingredients of Atovaquone/Proguanil may pass into breast milk and may harm your baby.
Other medicines and Atovaquone/Proguanil
Tell your doctor or pharmacist if you're taking any other medicines, or have recently taken any, including medicines you've bought without a prescription.
Some medicines can affect the way Atovaquone/Proguanil works, or Atovaquone/Proguanil itself can strengthen or weaken the effectiveness of other medicines taken at the same time. These include:
 metoclopramide, used to treat nausea and vomiting
 the antibiotics, tetracycline, rifampicin and rifabutin
 efavirenz or certain highly active protease-inhibitors used to treat HIV
 warfarin and other medicines that stop blood clotting
 etoposide used to treat cancer.
→ Tell your doctor if you are taking any of these. Your doctor may decide that Atovaquone/Proguanil isn't suitable for you, or that you need extra check ups while you're taking it.
→ Remember to tell your doctor if you start taking any other medicines while you're taking Atovaquone/Proguanil.

3. While you're taking Atovaquone/Proguanil
Taking Atovaquone/Proguanil with food and drink
Take Atovaquone/Proguanil with food or a milky drink, where possible. This will increase the amount of Atovaquone/Proguanil your body can absorb, and make your treatment more effective.
Driving and using machines
If you feel dizzy, do not drive. Atovaquone/Proguanil makes some people feel dizzy. If this happens to you, do not drive, use machines or take part in activities where you may put yourself or others at risk.
If you are sick (vomit)
For preventing malaria:
 if you are sick (vomit) within 1 hour of taking your Atovaquone/Proguanil tablet, take another dose straight away
 it is important to take the full course of Atovaquone/Proguanil. If you have to take extra tablets due to sickness, you may need another prescription.
 if you have been vomiting, it is especially important to use extra protection, such as repellents and bednets. Atovaquone/Proguanil may not be as effective, as the amount absorbed will be reduced.
For treating malaria:
 if you have vomiting and diarrhoea tell your doctor, you will need regular blood tests.
Atovaquone/Proguanil will not be as effective, as the amount absorbed will be reduced. The tests will check whether the malaria parasite is being cleared from your blood.
4. How to take Atovaquone/Proguanil
Always take Atovaquone/Proguanil exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure.
Take Atovaquone/Proguanil with food or a milky drink, where possible.
It is best to take Atovaquone/Proguanil at the same time each day.
To prevent malaria:
The usual dose for adults is 1 tablet once a day, taken as below.
Not for children, talk to your doctor.
Not recommended for preventing malaria in children, or in adults who weigh less than 40 kgs.
There may be a different type of Atovaquone/Proguanil tablet available for children in your country.
To prevent malaria in adults:
 start taking Atovaquone/Proguanil 1 to 2 days before travelling to an area which has malaria
 continue taking it every day during your stay
 continue taking it for another 7 days after your return to a malaria-free area.

To treat malaria
The usual dose for adults is 4 tablets once a day for 3 days.
For children the dose depends on their bodyweight:
 11-20 kg - 1 tablet once a day for 3 days
 21-30 kg - 2 tablets once a day for 3 days
 31-40 kg - 3 tablets once a day for 3 days
 over 40 kg - dose as for adults.
Not recommended for treating malaria in children who weigh less than 11 kgs.
For children who weigh less than 11 kgs talk to your doctor. There may be a different type of
Atovaquone/Proguanil tablet available in your country.
If you take too much Atovaquone/Proguanil
Contact a doctor or pharmacist for advice. If possible show them the Atovaquone/Proguanil pack.
If you forget to take Atovaquone/Proguanil
It is very important that you take the full course of Atovaquone/Proguanil.
If you forget to take a dose, don't worry. Just take your next dose as soon as you remember. Then continue your treatment as before.
Don't take a double dose to make up for a missed dose.
Don't stop Atovaquone/Proguanil without advice
Keep taking Atovaquone/Proguanil for 7 days after you return to a malaria-free area. Take the full course of Atovaquone/Proguanil for maximum protection. Stopping early puts you at risk of getting malaria, as it takes 7 days to ensure that any parasites that may be in your blood following a bite from an infected mosquito are killed.
5. Possible side effects
Like all medicines, Atovaquone/Proguanil can cause side effects, although not everybody gets them.
Look out for the following severe reactions. They have occurred in a small number of people, but their exact frequency is unknown.
Severe allergic reactions - signs include:
 rash and itching
 sudden wheezing, tightness of the chest or throat, or difficulty breathing
 swollen eyelids, face, lips, tongue or other part of the body.
→ Contact a doctor immediately if you get any of these symptoms. Stop taking Atovaquone/Proguanil.
Severe skin reactions
 skin rash, which may blister and looks like small targets (central dark spots, surrounded by paler
area with a dark ring around the edge) (erythema multiforme)
 severe widespread rash with blisters and peeling skin, particularly occurring around the mouth, nose, eyes and genitals (Stevens-Johnson syndrome).
→ If you notice any of these symptoms contact a doctor urgently.
Most of the other side effects reported have been mild and have not lasted very long.
Very common side effects

These may affect more than 1 in 10 people:
 headache
 feeling sick and being sick (nausea and vomiting)
 stomach pain
 diarrhoea.
Common side effects
These may affect up to 1 in 10 people:
 dizziness
 sleeping problems (insomnia)
 strange dreams
 depression
 loss of appetite
 fever
 rash which may be itchy
 cough
Common side effects, which may show up in your blood tests are:
 reduced numbers of red blood cells (anaemia) which can cause tiredness, headaches and shortness
of breath
 reduced numbers of white blood cells (neutropenia) which may make you more likely to catch
infections
 low levels of sodium in the blood (hyponatraemia)
 an increase in liver enzymes.
Uncommon side effects
These may affect up to 1 in 100 people:
 anxiety
 an unusual awareness of abnormal beating of the heart (palpitations)
 swelling and redness of the mouth
 hair loss.
Uncommon side effects that may show up in your blood tests:
 an increase in amylase (an enzyme produced in the pancreas).
Other side effects
 Other side effects have occurred in a small number of people but their exact frequency is unknown.
 Inflammation of the liver(hepatitis)
 blockage of the bile ducts (cholestatis)
 increase in heart rate (tachycardia)
 inflammation of the blood vessels (vasculitis) which may be visible as red or purple raised spots on the skin but can affect other parts of the body
 fits (seizures)
 panic attacks, crying
 seeing or hearing things that are not there (hallucinations)
 nightmares
 mouth ulcers
 blisters
 peeling skin
 increased sensitivity of the skin to sunlight.

Other side effects that may show up in your blood tests:
 A decrease in all types of blood cells (pancytopenia).
If you get any side effects
If any of the side effects gets serious or troublesome, or if you notice any side effects not listed in this leaflet:
→ Tell a doctor or pharmacist.
6. How to store Atovaquone/Proguanil
Keep Atovaquone/Proguanil out of the reach and sight of children.
Do not use Atovaquone/Proguanil after the expiry date printed on the carton.
Atovaquone/Proguanil does not require any special storage conditions.
If you have any unwanted Atovaquone/Proguanil, don't dispose of it in your waste water or household rubbish.
Take it back to your pharmacist who will dispose of it in a way that won't harm the environment.
7. Further information
What Atovaquone/Proguanil contains
The active ingredients are: 250 mg of atovaquone and 100 mg of proguanil hydrochloride in each tablet.

→ Tell your doctor, without taking Atovaquone/Proguanil if you might be allergic to any of these ingredients.
What Atovaquone/Proguanil looks like and contents of the pack
They are supplied in blister packs containing 12 tablets.

 


This leaflet was last revised in October 2011

Pack Size

12

More Info ..

To view this product's Patient Information Leaflet, click here.

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